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At intermediate doses, near the threshold concentration, CBD induces survival mechanisms, including cell cycle arrest and autophagy, and exerts an antagonistic effect on treatment with cisplatin

Ghods M., Georgiou I., Schmidt J., and Kruppa P., Disease Progression and Comorbidities in Lipedema Patients: A 10Year Retrospective Analysis, Dermatologic Therapy 33 (2020): e14534

Proc Natl Acad Sci USA 116:2599126000 Kirby J, Halligan E, Baptista MJ et al (2005) Mutant SOD1 alters the motor neuronal transcriptome: implications for familial ALS

Simultaneously, homologous arms including 500 bp upstream and downstream of the target gene MSMEG_5827 were amplified from WT_MS genomic DNA using primers containing regions flanking MSMEG_5827 by overlap PCR

That explanation might be partially right, but it could also be masking something more specific: low testosterone