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The answer is that, although the high-valent metal-oxo heme cores of these intermediates are in fact very similar, the substrate-binding cavities seem to differ substantially in how much access the substrate has to the iron center

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5.5 Engineered bacteria: metabolite-directed reprogramming of the tumor immune microenvironment Genetically engineered microorganisms represent a precision strategy to enhance cancer immunotherapy by delivering or modulating key microbial metabolites directly within the TME, thereby overcoming the limitations of systemic metabolite administration and inconsistent microbiome-driven metabolite production

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