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Death receptor pathways, such as CD95 (Fas/APO-1), can respond to exogenous and endogenous ROS in neutrophils, inducing apoptosis (107)

GSEA analysis revealed significant enrichment of IFN-I signaling pathways in the Lig group (Fig S6a), while the corresponding heatmap analysis confirmed upregulation of IFN-Iresponsive genes in Lig-derived neutrophils (Fig S6b)

Pex18p and Pex21p, a novel pair of related peroxins essential for peroxisomal targeting by the PTS2 pathway

All doses below come from published clinical trials, manufacturer guidelines, and established practitioner protocols as of February 2026

Biochem Biophys Res Commun 478, 162167