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In contrast, an increase in sub-visible particle count was seen after 21 days, and an increase in ThT fluorescence was seen after 28 days, in the case of co-formulation 1 containing HP-B-CD (Average MS: 0.92)

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10.1016/j.biopha.2021.111931 [DOI] [PubMed] [Google Scholar] 63.Chen L, Ruan G, Cheng Y, Yi A, Chen D, Wei Y

Seven days of L-citrulline supplementation at a daily dose of 2.4 g was shown to significantly increase plasma nitrite and nitrate, citrulline, and arginine

In other cases, some xenobiotics have been shown to undergo metabolic transformations that result, in part, in the formation of bis(glutathionyl) conjugates