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inhibitors of glutathione peroxidase Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel 4/mouse double minute 2 dual that inhibit breast adenocarcinoma cell proliferation Insights into the Role of
Description
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![inhibitors of glutathione peroxidase Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel 4/mouse double minute 2 dual that inhibit breast adenocarcinoma cell proliferation Insights into the Role of](https://www.mdpi.com/biomolecules/biomolecules-14-00689/article_deploy/html/images/biomolecules-14-00689-g004.png)
2017 doi: 10.1016/j.radphyschem.2017.09.015
![inhibitors of glutathione peroxidase Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel 4/mouse double minute 2 dual that inhibit breast adenocarcinoma cell proliferation Insights into the Role of](https://www.frontiersin.org/files/Articles/910292/xml-images/fphar-13-910292-g002.webp)
10.1530/REP-20-0015 48 MannervikB.linP.GuthenbergC.JenssonH.TahirM
![inhibitors of glutathione peroxidase Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel 4/mouse double minute 2 dual that inhibit breast adenocarcinoma cell proliferation Insights into the Role of](https://ars.els-cdn.com/content/image/1-s2.0-S0891584922004543-ga1.jpg)
Differently, P-SOH groups, produced when P-SH groups are oxidized by ROS, are rapidly neutralized by GSH
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Indeed, an increased risk of wheezing is associated with the presence of GSTM1 and GSTT1 genotypes, respectively, in mothers exposed to acetaminophen [101]
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