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Low soluble, unstable & rapidly autoxidizing Cystine Cannot Increase Cellular Glutathione GSH levels leading to gradual depletion chronic illness or ageing.

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Furthermore, some newly discovered potential pharmacological targets and newly studied antidepressants have attracted widespread attention, some reagents have even been approved for clinical treatment and some novel therapeutic methods such as phototherapy and acupuncture have been discovered to have effective improvement for the depressive symptoms