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In clinical deficiency states, mostly as a result of insufficient resorption of vitamin B12, such as after extensive resection of the small intestine and irritation of the small intestine (dysbiosis of the intestine), the resorption area in the intestine is reduced or blocked

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Ulanovskaya OA, Zuhl AM, Cravatt BF. NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink. Nat Chem Biol. 2013 May;9(5):300-6. doi: 10.1038/nchembio.1204. Epub 2013 Mar 3. PMID: 23455543; PMCID: PMC3631284

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