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Therefore, LPS-PLGA NPs can efficiently shift Th1 to Th2/Treg (Khakzad et al., 2019)

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In a randomised, double-blind, controlled trial of 400 mg/day of hydroxychloroquine versus placebo in patients with asymptomatic HIV infection and not on anti-retroviral therapy, hydroxychloroquine was found to be associated with an increased HIV viral RNA load as well as a faster decline in CD4 + cell counts, leading to the need to initiate anti-retroviral therapy [87]