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If orforglipron receives approval for obesity in April 2026, it will enter a market that Morgan Stanley estimates could reach $100 billion annually by the early 2030s, potentially transforming Eli Lilly's already dominant position in the metabolic disease space

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In the oxidative pathway, alcohol dehydrogenase (ADH) converts ethanol to acetaldehyde, a toxic by-product responsible for symptoms such as nausea, vomiting, and headaches (Mackus et al ., 2020)