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Effective melasma treatment includes removal of the excess melanin in the epidermis and dermis as well as suppression of further melanogenesis

Biochem J 431:16978 Garca-Gimnez JL, Markovic J, Das F, Queval G, Schnaubelt D, Foyer CH, Pallard FV (2013) Nuclear glutathione

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Methionine is an amino acid that helps prevent excess fat buildup in the liver and body

Current regulations require manufacturers to run these safety tests: Acute toxicity evaluation Skin irritation studies Dermal photoirritation assessment Mutagenicity/genotoxicity screening Extended duration (21-28 days) toxicity analysis [1] European regulation REACH makes industry stakeholders responsible for chemical substance safety