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22 Reverse Mendelian randomization evidence suggests that genetic susceptibility to Graves disease is associated with low circulating vitamin A, meaning that vitamin A deficiency promotes the development of autoimmunity in the genetically predisposed

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Finally, SLC7A11 mRNA was increased in healthy but not CD-derived macrophages treated with H 2 O 2 , suggesting defective defense mechanisms against ferroptosis due to the role of SLC7A11 in glutathione synthesis as a substrate for GPx

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