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For example, aging plasmacytoid dendritic cells (pDCs) exhibit limited production of IFN-I due to impaired IRF7 phosphorylation, resulting in decreased presentation of antigens to T lymphocytes

The significant decrease in ROS-mediated tube formation and wound healing in human microvascular endothelial cells (HMECs) after siRNA-mediated NOX4 knockdown further underscores its crucial role in angiogenesis and endothelial cell proliferation [51]

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K., Gabel, K., Freels, S., Rigdon, J., Rood, J., Ravussin, E., & Varady, K