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V.KuffovaL.DelibegovicM

Silva I

TF neutralizes iron-induced toxicity in iRPE cells Because lipid peroxidation leads to iron overload in iRPE cells, we further investigated the mechanisms of action of TF on iRPE cells exposed to FeCl 3 associated with nitrilotriacetate, which forms a stable iron complex in solution

These findings highlight that early-life Mn exposure has significant neurodevelopmental implications, with the developing brain being especially sensitive to Mn accumulation

Cells were fed every 3 days by removing half of the culture medium and replacing it with fresh cRPMI
