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Loss of Function Mutation of the Slc38a3 Glutamine Transporter Reveals Its Critical Role for Amino Acid Metabolism in the Liver, Brain, and Kidney. Pflgers Archiv 468: 213227
For example, the silent information regulator 1 (SIRT1), a NAD + -dependent protein deacetylase, functions as a key upstream regulator for LKB1/AMPK signaling in the liver 50
But its impact depends heavily on timing, consistency, and formulation
In the present study, an in vitro disease model of renal Fabry disease was developed
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