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As shown in Figure 4, IS can directly inhibit cell proliferation and reduce myogenic differentiation to myosin heavy chain through the increase in NOX-mediated ROS generation in murine C2C12 myoblast cells
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doi: 10.1289/ehp.10700 81 JiYTianYPanYShengNDaiHFanXet al
The patients whose results have been published have had homozygous mutations in the gene encoding the heavy subunit of the enzyme
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