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(Arg116Pro) has a Combined Annotation Dependent Depletion (CADD) score (v1.6) of 31 (Kircher et al., 2014) and is predicted as deleterious by multiple in silico-prediction programs and classified as a variant of uncertain significance, according to the ACMG classification criteria PM2, PP1, PP3, and PP4 (Richards et al., 2015)

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The data strongly suggest that using antioxidants could be really dangerous in lung cancer and melanoma, and possibly other cancers, he said

doi: 10.1073/pnas.0702268104

Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid: A 3-week multicentre randomized controlled trial (ALADIN Study)