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Therefore, the PFOS-mediated apoptosis started with ERK1/2 activation, which was followed by ER stress and autophagy induction

Among the remaining subjects, we further excluded those who received a diagnosis of bipolar disorder during the follow-up assessment (n = 9), those with missing metabolite data due to the lack of blood samples (n = 158) and those who did not complete the Inventory for Depressive Symptoms questionnaire (n = 33)

Once produced, TMA is absorbed into the bloodstream and transported to the liver, where it undergoes further oxidation to form TMAO via the enzyme FMO-3 [23, 25]