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Difficulties Translating Antisense-Mediated Activation of Frataxin Expression from Cell Culture to Mice

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These events can further affect nutrient absorption and gut motility, and become a vicious cycle causing symptoms such as constipation and muscle weakness, as well as neurological issues such as mood swings, fatigue , brain fog , etc

An RCT comparing the effects of duloxetine and pregabalin showed an improvement in WPI scores with a statistically significant difference between the two treatment arms in favour of duloxetine [8]