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Endocr Rev 18(6):801831 Durham SK, Mohan S, Liu F, Baker BK, Lee PD, Hintz RL, Conover CA, Powell DR (1997) Bioactivity of a 29-kilodalton insulin-like growth factor binding protein-3 fragment present in excess in chronic renal failure serum

For more severe cases or when systemic inflammation is significant, combining both provides broader coverage

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High stress levels stimulate cortisol production, which may disrupt melanocyte function, pushing hair toward early greying
