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32 However, the first integrative factor in Selyes stress adaptive response of the body, which could have a large range of beneficial effects that could be accordingly applied as the therapy, remains largely undiscovered

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It appears that the combination of early PD nonmotor symptoms with imaging of the nigrostriatal dopaminergic system offers a promising path toward the identification of PD biomarkers, which, once characterized, will set the stage for efficient use of neuroprotective agents that could slow down and alter the course of the disease

PMC 1133600