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For any in-vivo animal research conducted in the United Kingdom, full compliance with the Animals (Scientific Procedures) Act 1986 (ASPA) is mandatory, requiring valid Home Office licences and institutional ethical approval

National Heart Lung and Blood Institute

defense substances, against this relevant binding protein TC II is considered to be a possible cause (Takahashi et al., 2013)

The patient-reported benefit is real but confounded

The improvements could be due to placebo effect or the invasive procedure itself (cystoscopy), and subtle side effects might have gone unnoticed in such a small sample
