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It lies between the blood and the vessel wall, is synthesized and secreted by vascular endothelial cells, and is a dynamic natural barrier that is principally composed of proteoglycans, membrane glycoproteins, and plasma proteins, of which proteoglycans and glycoproteins are the main components (16)

A whole blood donation results in the loss of approximately 225-250 mg of iron [240, 241], which can lead to iron depletion and a subsequent decline in haemoglobin levels if donations are frequent

Flammer J, Haefliger IO, Orgul S, Resink T

Lutz, Paul Kievit, Anna Secher, Kirsten Raun, Martin G

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