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Pathol Int (2019) 69(7):4346

Reactive oxygen species (ROS) and free radicals generated during oxidative stress can cause oxidative damage to biomolecules such as lipids, proteins, and DNA, resulting in cellular dysfunction and tissue injury

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Clathrin-mediated endocytosis Clathrin-mediated endocytosis is the main process for the internalization of many NPs, which is used by all eukaryotic cells to internalize small particles and nutrients such as cholesterol
HER2 amplifications and mutations are considered to be usually unrelated and clinically distinct driver alterations that can be used to segment lung adenocarcinoma patients for targeted therapy [24, 25], and the development of drugs targeting HER2 remains an urgent clinical need [26]