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The cytokine cascade increases structural injury to the kidneys, aggravates function, and induces the progression of chronic kidney disease in the hypertensive population [80,141]

Unknown long-term effects Research deficiencies also mean a lack of information about the long term effects these substances may have on human bodies

Indications include: Medically refractory disease not responding to optimized biologic therapy Bowel obstruction from fibrostenotic stricture Intra-abdominal abscess not amenable to percutaneous drainage Complex perianal fistula (seton placement, diversion) Enterocutaneous or enterovesical fistula Dysplasia or cancer in Crohns colitis Free perforation (rare) Nutritional Therapy Exclusive enteral nutrition (EEN) effective for induction in pediatric Crohns