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This axis integrates nutrient signaling with oxidative stress defence, modulating glucose and lipid metabolism, mitochondrial function, and autophagy to maintain cellular stability

This resistance can be overcome by ibrutinib-mediated TFRC induction or via metabolic targeting of fatty acid metabolism

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Data collection encompassed demographic parameters, medical history, laboratory results, and oral examinations, which included evaluation of dry mouth, pain and burning in the mouth and on the tongue, pain in the angles of the mouth, bad breath, gingival bleeding, dysphagia and taste disorders using scales designed for this purpose, clinical and dental examination