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10.1016/S0735-1097(00)01093-7 [DOI] [PubMed] [Google Scholar] 228.Cui Y, Narasimhulu CA, Liu L, Zhang Q, Liu PZ, Li X, et al

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Specifically, KPV is a fragment of alpha-melanocyte-stimulating hormone (-MSH), a larger peptide with anti-inflammatory, antimicrobial, and fever-reducing properties.1 Even more specifically, the fragment in question is the C-terminal region of -MSH, which is particularly good at neutralizing pathogens.2 While many therapeutic peptides are taken exclusively by needle, KPV stands apart in that it can also be administered as an oral capsule or chewable tablet

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Neurological Function Score (Modified Longa System) Neurological deficits were evaluated 1 hour after ET-1 injection using the modified Longa scoring system: 0: No observable neurological deficit (excluded from analysis) 1: Failure to fully extend the left forepaw 2: Consistent circling to the left 3: Falling or leaning to the left side when ambulating 4: No spontaneous movement (severe infarction) Animals scoring between 1 and 3 were considered to have moderate ischemic deficits and were included in further analyses