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Studies in the rat
Our results revealed that MTX significantly induced the elevation of transaminases, alkaline phosphates (ALP), lactate dehydrogenase (LDH), and malonaldehyde (MDA) while depleting the levels of superoxide dismutase (SOD) and glutathione (GSH) when compared to the control group
It causes swelling in the deeper layers of skin, often around the face and lips
Klein S, Gastaldelli A, Yki-Jrvinen H, Scherer PE
