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Glycosidases are often overexpressed in certain pathological conditions, such as cancer or lysosomal storage diseases, making glycosidase-cleavable linkers an effective tool for achieving site-specific drug activation

Keap1, an E3 ubiquitin ligase and an inhibitor of the transcription factor nuclear erythroid-related factor 2 (NRF2), has recently been identified as a target of protein succination and consequent inactivation, which led to the induction of NRF2 and a potent antioxidant response 5,7