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10.1155/2016/3928714 135 RenY.ShenH

The parasite genome demonstrates significant instability characterized by aneuploidy, copy number variations (CNVs), and single nucleotide polymorphisms that collectively facilitate rapid adaptation to therapeutic interventions ( Leishmania to develop resistance through various mechanisms including altered drug transport, target modification, and enhanced metabolic detoxification pathways ( Leishmania serves as an evolutionary advantage, allowing rapid selection of resistant populations under drug pressure

10.1016/j.ejphar.2004.03.042

( Reference Campbell, Brown and Dufner 127 ) also studied the effect of milk proteins in healthy adult men (double-blind cross-over meal-challenge study)