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Regarding the dual valence-processing of rewarding/reinforcing stimuli within the mesocorticolimbic system and extended amygdala, it has been shown that activation of the glutamatergic projections from the amygdala through the bed nucleus of the stria terminalis to the ventral tegmental area (VTA) results in aversive and anxiogenic behaviors, whereas activation of the GABAergic parallel projections results in appetitive and anxiolytic behaviors (Jennings et al., 2013)
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However, the peptide itself is only part of the equation
Cathelicidins consist of an N-terminal cathelin-like sequence (~ 120-150 amino acids) and a C-terminal cationic antimicrobial domain (~10-95 AA) [102, 103]
To be more specific, periappendiceal fat stranding and appendiceal wall enhancement defect showed highest sensitivity, while extraluminal appendicolith, abscess, and extraluminal air showed highest specificity
