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Early human trials with single subcutaneous doses of SAR441255 in healthy subjects demonstrated improved glycemic control during a mixed-meal tolerance test, while also being well-tolerated

SIRT1, an NAD + -dependent deacetylase, regulates multiple critical processes, including lipid metabolism reprogramming, insulin signaling, oxidative stress response, autophagy, and immune balance, forming a regulatory network that spans metabolic, inflammatory, immune, and stress-related pathways

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doi: 10.1016/j.intimp.2017.11.021

Progress in Parkinson's disease-where do we stand