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In vascular cells, 17-estradiol (E2) can upregulate the expression and activity of PGC-1 in an estrogen receptor (ER)-dependent manner ( 3.3.2 Androgens and mitochondrial dysfunction: a potential driver of ferroptosis In contrast to the protective effects of estrogen, abnormal levels of androgens (either too high or too low) are closely associated with mitochondrial dysfunction and oxidative stress
Further investigation of the pathways involving GSH is expected to bring important insights into cancer (patho)physiology understanding ( Besides ATF4, another transcription factor that regulates xCT expression is the nuclear factor erythroid 2-related factor 2 (NRF2) via the antioxidant response element (ARE) present in the promoter region of xCT gene (40, 41)
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Caffeine's Effects on Glutathione Levels Research indicates that moderate coffee consumption may actually increase plasma glutathione levels
