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l-carnitine at 0.3 and 0.6 g/kg significantly upregulated hepatic protein levels of rPPAR- (Figure 2(b)), rCPT-1 (Figure 2(c)), rCPT-2 (Figure 2(d)) and rOCTN-2 (Figure 2(e)) in female and male rats, exhibiting fatty acid -oxidation acceleration

L-Carnitine is a naturally occurring amino acid derivative that plays a vital role in energy metabolism within the body

Moreover, G289A and T337I mutations are located proximal to the ATP-binding pocket of the C-terminal domain, G289A would cause steric conflict with Ser293, and T337I would cause a hydrophobic patch on the protein surface and reduce protein solubility

These findings suggest that enriched protein supplementation may support muscle preservation and metabolic health in this population