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Even though an excess of nicotinamide can recover the enzymatic activity, under physiological conditions the rate of dissociation is expected to be very slow [3]
This means you get the metabolic benefits of unlocking the fat cell vault without experiencing the jitters, anxiety, or racing heartbeat commonly associated with typical stimulant-based fat burners (like caffeine or ephedrine)
The levo for 7 odd yrs has made NO difference at all

CD38 in neurodegeneration and neuroinflammation
