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Our results are also consistent with publications showing that CAV-1 reduction upregulates angiogenesis-related factors as evidenced by an inverse correlation between CAV-1 and VEGF in osteosarcoma 28 , increased CXCR12 expression in CAV-1 silenced fibroblast 29 , and a significant negative correlation between osteopontin and caveolin-1 levels in human osteoarthritic cartilage 30

While bacteriostatic water is suitable for many research peptides, some may require specific solvents based on their chemical properties

Radiographic assessment demonstrated increased callus surface area, with quantitative histomorphometry confirming enhanced bone formation