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Vitamin B 1 deficiency causes overexpression of pro-inflammatory cytokines such as interleukin (IL)-1, IL-6, and tumor necrosis factor-alpha (TNF-) as well as increased expression of CD40 and CD40 ligand by microglial cells and astrocytes, which eventually leads to the death of neuron cells [18,19]

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20,23 Prevention The Institute of Medicine estimates that adults younger than 50 years absorb approximately 50 percent of dietary vitamin B 12 , and that between 10 and 30 percent of older patients may not be able to absorb adequate amounts from normal dietary sources