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These verdicts characterize the regulation of sortilin shedding and identify a novel mechanism by which sortilin ectodomain shedding acts as a regulatory switch for delivery of BDNF to the secretory pathway or to the lysosome, thus modulating the bioavailability of endogenous BDNF (Fig
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These results are consistent with the known mechanisms of oral semaglutide absorption, as demonstrated by human in vivo studies with radioactively labelled tablets [2]
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