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By incorporating multiple study designs, including RCTs, non-RCTs, and feasibility assessments, this review provides a broader perspective on VR interventions

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It also effectively modulates fibroblast activation, epithelialmesenchymal transition (EMT), and ECM remodeling ( This mechanism has been confirmed in MCT-induced experimental models of PAH: pulmonary TGF- signaling is markedly upregulated, whereas blocking TGF- receptor type I to inhibit excessive SMAD2/3 activation significantly attenuates vascular remodeling

[DOI] [PubMed] [Google Scholar] 208.Zambelli V.O., Fernandes A.C., Gutierrez V.P., Ferreira J.C., Parada C.A., Mochly-Rosen D., Cury Y

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