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37 Senescent fibroblasts promote degradation of the extracellular matrix (ECM) by secreting matrix metalloproteinase-1 (MMP1) and other proinflammatory factors, 38 ultimately leading to thinning of the epidermis and decreased barrier function, 39 while the selective removal of senescent cells leads to normalization of the ECM and a reduction in inflammation

There are minimal risks associated with the treatment, and side effects are rare

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Decrease dose consideration: Persistent side effects including headaches, fatigue, or injection site reactions, excessive response (extremely rapid weight loss suggesting dose may be higher than needed), cost concerns when lower doses might achieve similar results

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