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The CagriSema program, combining cagrilintide with semaglutide, has demonstrated: 15.1% mean body weight reduction at 32 weeks in REDEFINE 1 trial Approximately 15-17% weight loss in various phase 3 timepoints Superior outcomes compared to semaglutide monotherapy Manageable safety profile with expected GI side effects Cagrilintide 10mg remains an important research tool for scientists exploring amylin analogue applications

Heterogeneity was assessed quantitatively using the I2-statistics and Cochrans Q (Higgins and Thompson, 2002)

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Because of the retrospective nature of the study and the use of de-identified data, this study received an exemption waiver for approval and informed consent from the Institutional Review Board (IRB) of Chung Shan Medical University Hospital, identified by the reference number CS1-24047