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Notably, controlled fluid flow introduces sustained perfusion and physiologically relevant shear forces, both of which modulate cellular behaviour and allow for a more accurate assessment of nanoparticle transport, distribution and cellular uptake than static in vitro models [175, 176]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 149.Tapia-Arancibia L., Pares-Herbut N., Astier H

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doi: 10.3389/fphar.2014.00280 Received 01 October 2014 Accepted 02 December 2014 Published 18 December 2014 Volume 5 - 2014 Edited by Dominique Massotte, Institut des Neurosciences Cellulaires et Intgratives, France Reviewed by Chris Bailey, University of Bath, UK