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In this study, MOR triggered prolonged endosomal Gi/o signalling via trafficking of activated G proteins, independent of receptor internalization, revealing a distinct mechanism of endosomal GPCR signalling

Glucose-6-phosphate dehydrogenase (G6PD), a NADPH-generating enzyme, is the rate-limiting enzyme for the PPP

Detection of GSH in cell samples Hepa 16 cells (CL-0105, Procell) were cultured in DMEM medium (10% FBS and 1% penicillin/streptomycin) at 37 C in a humidified atmosphere containing 5% CO 2

Sanger sequencing revealed a germline insertion in NF1 exon 2 (c.165_166insCT), causing a frameshift and premature truncation that likely disrupted NF1 function in patient iPSCs (Fig