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Perhaps more importantly for tolerability, GIP activation seems to buffer against the nausea commonly caused by GLP-1 stimulation alone
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A C20 fatty diacid moiety is attached to the lysine residue at position 17 through an AEEA-Glu linker, supporting albumin binding and an extended pharmacokinetic half-life in research models
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doi: 10.1016/j.tins.2006.06.004 Zoroglu SS, Armutcu F, Ozen S, et al
And yes, its kind of outdated in some ways, but its really not in a lot of other ways because it gives you the basics
