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Authors concluded that, in the process of prostate carcinogenesis, activating histone modifications on GSTP1 are lost and subsequently DNA becomes methylated and inaccessible resulting in transcriptional silencing thus demonstrating interplay between histone reprogramming and promoter region methylation (Okino et al., 2007)
The proposed insights here underpin the imprinting role of cell metabolism in empowering cells with discrepant manifestations, some of which may ultimately drive carcinogenesis
avec vitamine C et slnium
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