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Liver protection from apoptosis requires both blockage of initiator caspase activities and inhibition of ASK1/JNK pathway via glutathione S-transferase regulation

The attenuation of JNK and NF-B is a critical finding since it has been previously shown that amyloid induces apoptosis through oxidative stress resulting from these pathways [35]

Ou, Y., Wang, S

However, cancer cells can escape cellular ferroptosis by activating or remodeling various signaling pathways, including oxidative stress pathways, thereby limiting the efficacy of ferroptosis-activating targeted therapy

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