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Doses greatly exceeding the nutritional requirements (for example, hundreds of milligrams daily) have not been studied in randomized trials for safety, so one should avoid mega doses in pregnancy unless treating a specific condition (such as pyridoxine-responsive seizures) under careful supervision

AOD9604 and hGH significantly upregulated 3-AR expression in the WAT of ob/ob mice, correlating with the observed reductions in adipose tissue mass

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