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Increasing lipophilicity of the therapeutic agents is a feasible method to improve the BBB permeability

2 Dose-response curve of the flinching response after intraperitoneal BPC-157 administration in the formalin test Fig

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However, a potentially transformative approach is being advanced to create axon guidance paths via factors secreted by host cells transfected with precise spatial precision (via stereotaxic microinjection) to overexpress growth factors, creating chemotaxic gradients to drive long-distance, targeted axonal outgrowth from endogenous and/or transplanted cells in the CNS