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Although both BacA and IcL groups displayed significant increases in CD4+ and CD4+CD45RO+ populations over time, only BacA induced an increase in the CD8+ population over time and a decrease in the FOXP3+ population at 14 weeks post-inoculation ( Figures 5E, F, H )

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In severe cases, neuropsychiatric symptoms can progress to include visual disturbances (which may reflect optic neuropathy), personality changes, or even psychosis, though these are less common