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It has been demonstrated that the expression of PON2 with intact lactonase activity facilitates 3OC12-HSL degradation in human airway epithelial cells and murine tracheal epithelial cells, suggesting that PON can disrupt the P

doi: 10.1186/s13017-018-0185-2

420 Cells isolated from AT patients were sensitive to radiation, indicating that ATM involves DNA repair

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Therefore, exploring dosing regimens that can distinguish between their anti-inflammatory effects and genotoxic effects (such as low-dose or intermittent administration) is a key direction for future research