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This could be due to its specific receptor interactions or ability to activate different signaling pathways compared to more potent estrogens [69,70]

Cell (2022) 185(19):35013519.e20

Catechol-O-methyltransferase Polymorphism Is Associated with Increased Uterine Leiomyoma Risk in Different Ethnic Groups

a Y refers to the medication 4.6 Antioxidant activity Altered oxidative status may have peroxidative effects on lipids, proteins, and RNA and regulate cellular responses, signal transduction, and metabolism, thereby impairing their biological functions

While these suggest a favorable profile at moderate doses, large-scale human clinical trials haven't been conducted